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Resolution to - IE-10 Script Error __doPostBack is undefined in .Net Framework 4.0

Fixed:- IE-10 UpdatePanel PostBack Issue with ASP.Net Framework 4.0

IE10 has a new user agent which requires an update of your ASP.NET browser definition files.

As IE10 is a new browser so it has new browser definition which was not included in .Net Framework 4.0.

Resolution:- Install Hotfix for the same from here :-

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